Pork Tenderloin Pasta

ziti pasta serve with pork tenderloin on a turquoise plate.

4.7 from 3 reviews

Pork tenderloin pasta recipe features medallions tossed with a flavorful sauce made with onions, garlic and mushrooms.


  • 4 tablespoons olive oil, divided
  • 1 medium onion, thinly sliced
  • 5 mushrooms, chopped (I used baby bella)
  • 2 cloves garlic, minced
  • 1 medium pork tenderloin, about 1.25 pounds
  • 1/2 cup dry red wine
  • 1/2 cup chicken broth, low sodium
  • 3 tablespoons butter
  • 1/3 cup basil, minced
  • 1/2 tsp salt
  • 1 tablespoon balsamic vinegar
  • 12 ounces short pasta, such as ziti
  • grated Parmigiano or Pecorino Romano cheese for topping


  1. Preheat the oven to 200 degrees and start boiling water . Heat 1 tablespoon olive oil in a large skillet on medium heat, then add the onion. Sauté the onion, stirring occasionally, for at least 10 minutes so it starts to get caramelized. You can prepare the other ingredients as the onion cooks.
  2. Prepare the pork by slicing it into 1 inch thick medallions. Set the medallions out in a plate in a single layer, and sprinkle with 1/2 teaspoon of salt.
  3. Cook the pork: when the onions have caramelized, push the onions to the edges of the skillet. Add another tablespoon olive oil, on medium heat. Add half of the pork tenderloin medallions in a single layer. Cook for 3 minutes, then turn the pork over and cook for another 3 minutes. After 6 minutes cooking time, move the pork to a baking dish. Repeat the process with the 2nd half of the pork. After putting the 2nd batch of pork into the baking dish, move it to the oven. Leave the pork in the oven for 10 minutes to stay warm and finish cooking, while you make the sauce.
  4. Add the pasta to the boiling water after the first batch of pork has been removed from the skillet. Cook according to package directions. Reserve 1/3 cup pasta cooking water.
  5. After the moving the 2nd batch of pork from the skillet, add the final tablespoon olive oil to the skillet. Stir the onions to distribute evenly, and add the chopped mushrooms to the skillet. Let the mushrooms cook for a couple of minutes, then stir in the red wine and the garlic. Cook for a few more minutes, then stir in the broth. Simmer for about 5 minutes, stirring occasionally.
  6. Remove the pork from the oven after 10 minutes. Drain the pasta when done to your liking. Gradually add the pasta to the skillet, stirring to coat with the sauce. Add the basil and balsamic vinegar, along with the reserved pasta cooking water, then stir in the pork.
  7. Plate the pork tenderloin pasta, topped with grated Parmigiano cheese. Enjoy!


  • Prepare the other ingredients as the onion caramelizes in the skillet to save time.
  • Start cooking the pasta after the first batch of pork has been removed from the skillet.

Keywords: pork tenderloin and pasta, pork tenderloin pasta recipe, pasta with pork

Recipe Card powered byTasty Recipes